陕西医学杂志Issue(3)：287-290,4.DOI:10.3969/j.issn.1000-7377.2016.03.011
D-二聚体和纤维蛋白原在冠心病早期病情评估中的临床意义
Clinical significance of D-dimer and fibrinogen in early diagnosis of coronary heart disease
摘要
Abstract
Objective :To investigate the clinical significances of plasma D-dimer (D-D)and fibrinogen (Fg)in early diagnosis of coronary heart disease (CHD ) .Methods :412 subjects were divided into control group (coronary artery stenosis was less than 50% ) ,single-vessel group ,double-vessel group and multiple-vessel group (coronary artery stenosis was more than 50% ) .Meawhile ,according to clinical manifestations and diagnosis stand-ard ,all patients were classified into normal control group(NC) ,stable angina pectoris group(SAP) ,unstable angina pectoris group(UAP) and acute myocardial infarction group (AMI) .The level of D-D and Fg were measured and compared among groups .Results :D-D ,Fg and creatine kinase-MB (CK-MB) in AMI group were significantly high-er than those of NC group (P < 0 .05) .Fg and CK-MB in AMI group were higher than those of SAP and UAP groups (P< 0 .05) .D-D ,Fg and CK-MB in multiple-vessel group were significantly higher than those of normal control and single-vessel groups (P< 0 .05) .Fg in double-vessel group was significantly higher than its of single-ves-sel group (P< 0 .05) .CK-MB in multiple-vessel group was significantly higher than its of double-vessel group (P<0 .05) .The area under curve (AUC) of D-D ,Fg and CK-MB was 0 .612 ,0 .589 and 0 .692 .Conclusion :The detec-tion of D-D ,Fg and CK-MB contribute to diagnose and type of CHD ,and the concentration is related to severity of coronary artery lesions .关键词
D-二聚体/纤维蛋白原/分析/冠状动脉疾病/诊断/危险性评估Key words
D-dimer/Fibrinogen/analysis/Coronary disease/diagnosis/Risk assessment分类
医药卫生引用本文复制引用
郭旗,龙泳,权晓慧,郭瑄,马维冬,贾珊,韩振华,王聪霞,张岩,张春艳,张琳,李永勤..D-二聚体和纤维蛋白原在冠心病早期病情评估中的临床意义[J].陕西医学杂志,2016,(3):287-290,4.基金项目
国家自然科学基金资助项目（81273828） 陕西省社会发展科技攻关项目 （）
