实用医学杂志2016，Vol.32Issue(1)：54-57,4.DOI:10.3969/j.issn.1006-5725.2016.01.017
联合应用右美托咪定和舒芬太尼对尼古丁高依赖患者食管癌术后镇痛效果的影响
Effect of combination of dexmedetomidine and sufentanil on postoperative analgesia for highly nicotine dependent patients undergoing esophagectomy
摘要
Abstract
Objective To observe the effect of combination of dexmedetomidine and sufentanil on postoperative analgesia for the highly nicotine dependent patients undergoing esophagectomy. Methods Ninety highly nicotine dependent patients undergoing esophagectomy were randomly allocated into three groups (n = 30 each): low-dose sufentanil group (Group S1), high-dose sufentanil (Group S2), dexmedetomidine and sufentanil group (Group DS). All patients of three groups received postoperative PCIA with following setting: 2 mL/h;bolus: 2 mL; lock time: 5 min; 4 hours limited: 40 mL. The scores of VAS and Ramsay, effective presses/total presses of PCIA, the consumption of sufentanil during 72 h after operation, side effects and the satisfaction degree of patients were recorded. Results Compared with those of group S2, the scores of VAS (both at rest and movement) decreased significantly in group DS from 1 h to 8 h (P<0.05). Compared with those of group S1, the scores of VAS (both at rest and movement) decreased significantly in group S2 and DS from 1 h to 72 h (P<0.05). Compared with that in group S1 and S2, the consumption of sufentanil during 72 h after operation decreased significantly in group DS (P < 0.05). Compared with those in group DS, The numbers of nausea and vomiting were significant decreased in group S1 and S2(P < 0.05). Compared with those in group S1, the remedial cases were significantly decreased in group S2 and group DS (P < 0.05). Conclusion The effect of combination of dexmedetomidine and sufentanil is superior to that of sufentanil in terms of postoperative analgesia in highly nicotine dependent male patients undergoing esophagectomy.关键词
食管肿瘤/右美托咪定/舒芬太尼/尼古丁/术后镇痛Key words
Esophageal cancer/Dexmedetomidine/Sufentanil/Nicotine/Postoperative analgesia引用本文复制引用
任春光,李长营,高秀娟,张栋,张学俊..联合应用右美托咪定和舒芬太尼对尼古丁高依赖患者食管癌术后镇痛效果的影响[J].实用医学杂志,2016,32(1):54-57,4.基金项目
国家自然科学基金面上项目(编号:81471134) （编号:81471134）
