土壤学报2016，Vol.53Issue(1)：12-15,4.DOI:11766/trxb201511240538
2015年诺贝尔生理学或医学奖的启示 ——土壤微生物分离培养推动了寄生虫病防治
2015 Nobel Prize and Soil Microbiology ——Culture-dependent Study Warrants More Attention
摘要
Abstract
In 1974,Satoshiōmura,a Japanese microbiologist and expert in isolating natural products,isolated new strains of Streptomyces from soil samples. He found that this strain can produce a bioactive compound named Avermectin,which was subsequently chemically modified to a more effective compound called Ivermectin by Williman Campbell from Merck Company. Ivermectine was later tested in humans with parasitic infections and effectively killed parasite larvae,leading to a Nobel Prize in 2015. The rapid advance of new techniques such as single-cell isolation and high-throughput screening may revolutionize culture-dependent study and downstream applications. This will dramatically change the landscape of DNA/RNA-based research of microbial resource on Earth,and soil microbiology represents one of the most important research fields in future.关键词
土壤微生物/诺贝尔奖/抗生素/分离培养Key words
2015 Nobel Prize in Physiology or Medicine/Soil microbe/Antibiotic/Culture-dependent technique分类
生物科学引用本文复制引用
贾仲君..2015年诺贝尔生理学或医学奖的启示 ——土壤微生物分离培养推动了寄生虫病防治[J].土壤学报,2016,53(1):12-15,4.基金项目
中国科学院战略性先导科技专项(B类)"土壤-微生物系统功能及其调控"(XDB15040000)资助 Supported by the Strategic Priority Research Program(B)of the Chinese Academy of Sciences,China Soil Microbiome Initiative(No.XDB15040000) （B类）
