现代妇产科进展2016，Vol.25Issue(2)：97-99,105,4.DOI:10.13283/j.cnki.xdfckjz.2016.02.005
Pak4在子宫内膜癌组织中的表达及临床意义
Expression and clinical significance of Pak4 in endometrial cancer
摘要
Abstract
Objective:To assess the expressions of Pak4 and phosphorylated Pak4 ( p-Pak4 ser474 ) in endometrial cancer tissues and correlated with clinicopathological parameters. Methods:The expressions of Pak4 and p-Pak4ser474 were examined by immunohistochemistry. We calculated a composite histoscore to account for both stain intensity and uniformity. The ex-pressions of Pak4 and p-Pak4 ser474 in endometrial cancer tissues were assessed and correlated with clinicopathological parameters. Results:Pak4 and activated Pak4 expression were signifi-cantly increased in atypical endometrial hyperplasia (histoscore=7. 20±1. 10,6. 80±1. 10) and invasive cancers (histoscore=9. 69±2. 83,8. 81±3. 04) compared with normal endometrium (histoscore=4. 00±2. 88,2. 87±2. 28). Both were even higher in lymph node metastases (his-toscore=12. 00 ±0. 00,11. 60 ±1. 27). We found a significantly positive correlation between Pak4 and p-Pak4 expression with disease stage (P=0. 003,0. 001),poor histological differenti-ation(P=0. 001,<0. 001),depth of myometrial invasion (P=0. 029,0. 009),vascular space invasion (P=0. 046,0. 005) in endometrial cancer. Conclusion:Pak4 expression is specifical-ly increased in the most advanced lesions, suggesting that overexpression and/or activation of Pak4 might contribute to malignant progression of human endometrial cancer.关键词
p21-激活激酶4/子宫内膜癌Key words
Pak4/Endometrial cancer分类
医药卫生引用本文复制引用
陆雯,苏涛,张慧娟,万小平..Pak4在子宫内膜癌组织中的表达及临床意义[J].现代妇产科进展,2016,25(2):97-99,105,4.基金项目
国家自然科学基金(No:81402144,81272885,81472427) （No:81402144,81272885,81472427）
同济大学青年优秀人才培养行动计划(No:1400804) （No:1400804）
上海青年医师培养资助计划(第三批) （第三批）
