中国组织工程研究Issue(2)：267-272,6.DOI:10.3969/j.issn.2095-4344.2016.02.020
信号通路在膝骨关节炎实验研究中的进展
Experimental progress of signal transduction pathways in knee osteoarthritis
摘要
Abstract
BACKGROUND:Studies have shown that signaling pathway plays an important role in the pathogenesis of knee osteoarthritis. OBJECTIVE: To elaborate the experimental progress of signal transduction pathway in knee osteoarthritis METHODS: A computer-based retrieval of PubMed, CNKI, VIP and Wanfang databases was performed to find the relevant literatures concerning experimental studies of signaling pathway in knee osteoarthritis. Al data were primarily screened to exclude repeated and irrelevant articles. Articles about association between knee osteoarthritis and signal pathway were included.RESULTS AND CONCLUSION:A total of 51 articles were colected, including 20 in Chinese and 31 in English. It is concluded that the signal transduction pathway related to knee osteoarthritis is mainly concentrated in the two aspects: the proliferation of chondrocytes and the apoptosis of chondrocytes. The signal transduction pathways related to the proliferation of chondrocytes mainly include Notch signaling pathway and Wnt signaling pathway. SDF-1/CXCR4 signaling pathway, TLR4 signaling pathway, and MAPKs signaling pathway are associated with apoptosis in chondrocytes. Hippo-YAP signaling pathway and ERK1/2 signaling pathway have a double role in the regulation of proliferation and apoptosis of chondrocytes.关键词
组织构建/软骨组织工程/信号通路/骨关节炎,膝/软骨细胞/综述分类
医药卫生引用本文复制引用
王华敏,宓轶群,刚嘉鸿..信号通路在膝骨关节炎实验研究中的进展[J].中国组织工程研究,2016,(2):267-272,6.基金项目
课题由上海市卫生和计划生育委员会、上海市中医药发展办公室上海市中医药三年行动计划项目(zy3-pcpy-3-1018)资助@@@@the Three-Year Action Plan Project of Shanghai Traditional Chinese Medicine of Shanghai Municipal Commission of Health and Family Planning and the Ofice of Chinese Medicine Development, No. zy3-pcpy-3-1018 （zy3-pcpy-3-1018）
