摘要
Abstract
Objective To study the effect of atorvastatin on endothelial function in patients with coronary heart disease. Methods 121 patients with coronary heart disease were randomly divided into two groups. 62 cases of control group received routine therapy, while 59 cases of study group were given atorvastatin on the basis of routine therapy. Before treatment and 4 weeks after treatment, the NO, NOS, asymmetric dimethylarginine, relative expression of eNOS mRNA, and brachial artery flow mediated dilation function (FMD) were detected. Results After 4 weeks, the percentage of FMD in the study group increased by (2.44 ± 0.11) %, the eNOSm/GAPDH gray value increased by 0.25 ± 0.05 , the serum levels of NO and NOS were significantly higher than those before treatment, and the content of ADMA was significantly lower than that before treatment; All the differences were statistically significant (P <0.05). All the indicators 4 weeks after treatment showed statistically significant difference between two groups (P<0.05). Conclusions Atorvastatin can increase the secretion of NO, improve the utilization of lipid deposition, and affect the endothelial function, so as to treat coronary heart disease.关键词
瑞舒伐他汀/冠心病/一氧化碳合酶/内皮功能/影响Key words
Atorvastatin/Coronary heart disease/Carbon monoxide synthase/Endothelial function/Influence分类
医药卫生
