医药导报Issue(2)：175-177,3.DOI:10.3870/j.issn.1004-0781.2016.02.018
星点设计-效应面法优化白芍提取工艺∗
Optimization of Extraction Process for Paeoniae radix Alba by Central Composite Design-Response Surface Methodology
摘要
Abstract
Objective To optimize the extraction process of Paeoniae radix alba. Methods Extraction rates of paeoniflorin and total glucosides from Paeoniae radix alba and yield of dry extract were served as research indexes. Extraction process was optimized by central composite design-response surface methodology. Results Optimum condition of extraction technology was to extract 2 times with 9-fold of 85.00% ethanol for 100 min each time. Results of the three batches of confirmatory test were accordant with the predicted values. Conclusion The observed and predicted values were close to each other,and the optimum formulation by CCD-RSM was successful. The established model has a reliable predictability. The optimum extraction process is reasonable,stable and feasible.关键词
白芍/芍药苷/芍药总苷/星点设计-效应面法Key words
Paeoniae radix alba/Paeoniflorin/Total glucosides of Paeoniae radix alba/Central composite design-response surface methodology分类
医药卫生引用本文复制引用
魏词,万蒞,王红,黄国军..星点设计-效应面法优化白芍提取工艺∗[J].医药导报,2016,(2):175-177,3.基金项目
湖北省教育厅科研项目( D20101806) （ D20101806）
