中国临床医学Issue(6)：734-737,4.
Alpha B-crystallin 蛋白 Ser59磷酸化在肝细胞肝癌中的意义
Significance of Phosphorylated Alpha B-Crystallin (Ser59) in Hepatocellular Carcinoma Tissues
摘要
Abstract
Objective :To investigate the expression of phosphorylated alpha B-crystallin in hepatocellular carcinoma(HCC) tissues and its significance .Methods : The expression level of phosphorylated alpha B-crystallin in HCC tissues from 403 cases was detected by immunohistochemical staining ,and its correlation with HCC clinicopathologic features and prognosis was analyzed .Results : The expression level of phosphorylate alpha B-crystallin (Ser 59 ) was correlated with tumor size ,tumor encapsulation ,vascular invasion and tissue differentiation ( P < 0 .05 or 0 .01) . However ,it was not correlated with age , gender ,HBsAg ,liver cirrhosis .Multivariate analysis showed that the expression level of phosphorylated alpha B-crystallin (Ser 59 ) was an independent factor for prognosis .Conclusions : The expression level of phosphorylated alpha B-crystallin (Ser 59 ) is correlated with the malignant phenotype and poor prognosis of HCC .关键词
磷酸化 alpha B-crystallin/肝细胞肝癌/预后Key words
Phosphorylated alpha B-crystallin/Hepatocellular carcinoma/Prognosis分类
医药卫生引用本文复制引用
黄晓勇,柯爱武,施国明,周俭..Alpha B-crystallin 蛋白 Ser59磷酸化在肝细胞肝癌中的意义[J].中国临床医学,2015,(6):734-737,4.基金项目
国家自然科学基金项目 （）
