中国免疫学杂志Issue(1)：90-91,96,3.DOI:10.3969/j.issn.1000-484X.2016.01.019
VEGF和突变型p53在胃癌组织表达及意义
VEGF and mutant p53 expression in gastric carcinoma and significance
摘要
Abstract
Objective:To detect precancerous lesions of gastric cancer and biopsy tissue vascular endothelial growth factor (VEGF)and mutant p53 gene(mtp53)expression,to explore the development of clinical significance of VEGF and mutant p53 gene in gastric cancer.Methods:19 cases by endoscopic biopsies of normal gastric tissues,22 cases of intestinal metaplasia,47 cases of gastro-intestinal mucosal dysplasia, 54 cases of gastric cancer samples by immunohistochemical staining to detect the expression levels of VEGF and mtp53′s.Results: The expression levels of VEGF, mtp53 in normal gastric mucosa, intestinal metaplasia, dysplasia, and gradually increased gastric cancer was the law.mtp53 of VEGF expression in gastric carcinoma and compared with normal gastric tissue,intestinal metaplasia was significantly higher(P<0.05),but with atypical hyperplasia was no significant difference(P>0.05). Conclusion: The abnormal expression of VEGF and mutant p53 may be related to the degree of deterioration of the stomach tissue lesions related.关键词
VEGF/突变型p53/胃癌/癌前病变Key words
VEGF/Mutant p53/Gastric cancer/Precancerous lesions分类
医药卫生引用本文复制引用
穆桂芳,周利克,陈文军,穆雪峰,毕海静,曲玲,谭悦菊,孙光喜,董祟海,白厚桥,高才华..VEGF和突变型p53在胃癌组织表达及意义[J].中国免疫学杂志,2016,(1):90-91,96,3.基金项目
本文为胃癌组织中VEGF及突变型p53基因表达及临床意义研究（No．2012GNS042－1）项目。 （）
