中国药科大学学报Issue(1)：19-29,11.DOI:10.11665/j.issn.1000-5048.20160103
磷酸化蛋白质组学富集策略进展及其在疾病研究中的应用
Advances in enrichment strategies for phosphoproteomics and appIication of phosphoproteomics in disease research
摘要
Abstract
Protein phosphorylation is one of the most common post-translational modifications (PTMs)in various organisms,which plays critical roles in the regulation of intracellular biological processes,such as cell prolifera-tion,signal transduction,metabolismis and tumorigenesis.However,the low abundance of phosphoprotein in the biological systems poses significant challenges of current analytical techniques.In order to further understand the phosphoproteomics,the roles of phosphorylated proteins in life process,discovery of biomarkers,diagnosis and treatment of disease,enrichment strategies of high efficiency have been developed,including the design of new nanomaterials and combination of a variety of analytical methods,et al.In this paper,we reviewed the develop-ment of enrichment strategies for phosphoproteomics and application of phosphoproteomics in disease.关键词
磷酸化蛋白质组学/富集策略/新材料/疾病研究Key words
phosphoproteomics/enrichment strategy/new material/disease research分类
医药卫生引用本文复制引用
武维新,严佳,谭喜莹,李博,苏梦翔,严方,狄斌..磷酸化蛋白质组学富集策略进展及其在疾病研究中的应用[J].中国药科大学学报,2016,(1):19-29,11.基金项目
国家自然科学基金资助项目（No．81202500）；江苏省自然科学基金资助项目（No．BK20141356）；药物质量与安全预警教育部重点实验室资助项目（No．DQCP2015MS05）This work was supported by the National Nature Science Foundation of China (No．81202500)；the Natural Science Foundation of Jiangsu Province (No．BK20141356)；and the Open Project Program of MOE Key Laboratory of Drug Quality Control and Pharmaco-vigilance(No．DQCP2015MS05) （No．81202500）
