中国药科大学学报Issue(1)：95-100,6.DOI:10.11665/j.issn.1000-5048.20160114
生脉散对失衡人肠道菌群的调节作用
In vitro study on the reguIation of Sheng-mai San on dysbacteriosis of intesti-naI fIora
摘要
Abstract
To study the regulation effect of Sheng-mai San (SMS)on intestinal dysbacteriosis,ceftriaxone sodium was used to induce intestinal dysbacteriosis in vitro,the bacteria were cultured in the selective medium and enu-merated by plat counting method,and the short chain fatty acid were also analyzed .The results showed that SMS (16.5,11.2,5.5 mg/mL)could significantly inhibit the proliferation of potentially harmful bacteria such as Enterococci,Enterobacteriaceae and promote the proliferation of Lactobacillus and Clostridum.Compared with the model group,the proliferation of Enterococci and Enterobacteriaceae was inhibited by 24.9% and 19.1%,while the proliferation of Lactobacillus and Clostridum was increased by 22.3% and 25.8% respectively in the middle-concentration of SMS group (11.2 mg/mL)at 24 h.Meanwhile,SMS in different concentration significantly increase the accumulation of acetic acid and propionic acid generated by gut microbes which could significantly inhibit the proliferation of harmful bacteria.And SMS showed prebiotic effects on intestinal microflora imbalance induced by antibiotics in vitro.关键词
生脉散/肠道菌群/益生菌/短链脂肪酸Key words
Shengmai San/intestinal flora/prebiotics/short-chain fatty acid分类
医药卫生引用本文复制引用
花海莹,李雪晴,刘吉华..生脉散对失衡人肠道菌群的调节作用[J].中国药科大学学报,2016,(1):95-100,6.基金项目
国家自然科学基金资助项目（No．81173471）This study was supported by the National Natural Science Foundation of China (No．81173471) （No．81173471）
