中国药房2016，Vol.27Issue(5)：627-631,5.DOI:10.6039/j.issn.1001-0408.2016.05.16
我中心儿童青少年患者使用抗精神病药的不良反应报告分析
Analysis of ADR Reports Caused by Psychotropic Drugs in Children and Adolescent of Our Center
摘要
Abstract
OBJECTIVE:To investigate the characteristics of ADR induced by psychotropic drugs in children and adolescent of our center,and to provide reference for clinical drug use. METHODS:ADR induced by psychotropic drugs in children and adoles-cent reported by our center from 2005 to 2015 were investigated and analyzed retrospectively. RESULTS:A total of 177 ADR were collected,of which the most cases were induced by antipsychotic drugs as risperidonal,olanzapine and quetiepine. The most com-mon ADR were central and peripheral nervous system disorders(117 cases,37.86%),followed by endocrine disorder(35 cases, 11.32%),heart rate and rhythm disorders(32 cases,10.35%)and liver and biliary system disorders(17 cases,5.50%). By the relative titer of haloperidol,most of ADR were induced by haloperidol with dose of 4 mg,6 mg and 8 mg once a day(34,29 and 53 cases). Most of cases occurred within a week(94 cases,53.11%). CONCLUSIONS:To develop and strengthen clinical applica-tion and ADR monitoring of psychotropic drugs in children and adolescents should be regarded as the key to ensure drug use safety.关键词
儿童青少年/抗精神病药/药品不良反应/用药安全Key words
Children and adolescents/Psychotropic drugs/Adverse drug reaction/Drug use safety分类
医药卫生引用本文复制引用
马燕,毛叶萌..我中心儿童青少年患者使用抗精神病药的不良反应报告分析[J].中国药房,2016,27(5):627-631,5.基金项目
上海交通大学医学院附属精神卫生中心院级课题(No.2014-YJ-12) （No.2014-YJ-12）
