中国药房2016，Vol.27Issue(5)：642-644,3.DOI:10.6039/j.issn.1001-0408.2016.05.20
斑点追踪成像技术在慢性心力衰竭药物疗效评价中的应用
Application of Speckle Tracking Imaging in the Evaluation of Chronic Heart Failure
摘要
Abstract
OBJECTIVE:Taking metoprolol succinate sustained-release tablets as an example,to explore the value of speckle tracking imaging in therapeutic efficacy evaluation of CHF drugs. METHODS:68 CHF patients who had never underwent regular treatment were given Metoprolol succinate sustained-release tablets and anti-heart failure agents for 3 months. NYHA classification, resting heart rate(RHR),6 min walk distance(6MWD)and conventional echocardiographic measurements were tested before and 1 and 3 months after treatment. Dynamic image were collected in the apical 2-chamber view,apical 4-chamber view and left ven-tricular long axis plane for speckle tracking imaging offline analysis. The left ventricular global longitudinal strain (LVGLS) were measured. After 3 months of treatment,CHF patients were divided into standard group(group A,RHR 55-60 times/min)and non-standard group (group B,RHR>60 times/min) according to resting heart rate. The improvement of above indicators were com-pared between 2 groups,and that of LVGLS was also compared. RESULTS:After 1 month of treatment,RHR,LVEDd,LVEF and LVGLS of group A were improved significantly,compared with group B,with statistical significance (P<0.05). After 3 months of treatment,there was statistical significance in above indicators between 2 groups(P<0.05). In group A,RHR,6MWD and LVGLS improved significantly after 1 month of treatment,there was statistical significance,compared with before treatment (P<0.05);there was statistical significance in above indicators after 3 months of treatment,compared with before treatment and after 1 month of treatment (P<0.05). In group B,RHR and 6MWD improved significantly after one month of treatment;there was statistical significance,compared with before treatment(P<0.05);there was statistical significance in significant improvement of each indicator between after 3 months of treatment and before treatment (P<0.05);only there were statistical significance in RHR and NYHA grading,compared with after one month of treatment(P<0.05). CONCLUSIONS:Speckle tracking imaging can early reflect the left ventricular function improvement of CHF patients after anti-heart failure treatment,especially in patients with RHR control standard earlier and more significant. Speckle tracking had good clinical application value in the follow-up treatment of heart failure as routine evaluation index.关键词
斑点追踪成像技术/琥珀酸美托洛尔缓释片/静息心率/慢性心力衰竭Key words
Speckle tracking imaging/Metoprolol succi-nate sustained-release tablets/Resting heart rate/Chronic heart failure分类
医药卫生引用本文复制引用
廖康腊,张晓刚,秦俭,廖慧,刘莉..斑点追踪成像技术在慢性心力衰竭药物疗效评价中的应用[J].中国药房,2016,27(5):642-644,3.基金项目
国家临床重点专科建设项目(No.财社〔2011〕170号) （No.财社〔2011〕170号）
