中国药房2016，Vol.27Issue(5)：653-654,2.DOI:10.6039/j.issn.1001-0408.2016.05.24
血必净注射液对脓毒症患者凝血功能及预后的影响
Effects of Xuebijing Injection on Blood Coagulation Function and Prognosis of Sepsis Patients
摘要
Abstract
OBJECTIVE:To investigate the effect of Xuebijing injection on coagulation function and prognosis in patients with sepsis. METHODS:50 patients with sepsis were randomly divided into control group and observation group according to the hospi-talization sequence,with 25 cases in each group. Control group received conventional treatment,and observation group was addi-tionally given Xuebijing injection(50 ml added into 5% Glucose solution or 0.9% Sodium chloride solution 250 ml intravenously, bid) on the basis of conventional treatment. Treatment course lasted for 7 d. The coagulation function,APACHE Ⅱscore after 7 days of treatment and 28 d mortality were compared between 2 groups. RESULTS:After 7 d treatment,the coagulation indexes were improved significantly in 2 groups compared with before treatment,and the APACHEⅡscores were decreased significantly in both groups;the observation group were significantly better than the control group,with statistical significance (P<0.05). After followed up for 28 d,the mortality rate of 2 groups were 16% and 28%,there was no statistical significance (P>0.05). CON-CLUSIONS:Xuebijing injection can inhibit blood clotting activation,correct the coagulation disorders,and improve the sepsis se-verity.关键词
血必净注射液/脓毒症/凝血功能/预后Key words
Xuebijing injection/Sepsis/Coagulation function/Prognosis分类
医药卫生引用本文复制引用
林秀娟,唐纪文,钟丽红,程小明..血必净注射液对脓毒症患者凝血功能及预后的影响[J].中国药房,2016,27(5):653-654,2.基金项目
惠州市科技计划项目(No.20140801) （No.20140801）
