中国药房2016，Vol.27Issue(5)：671-673,3.DOI:10.6039/j.issn.1001-0408.2016.05.31
国产甲磺酸伊马替尼片治疗慢性粒细胞白血病的临床观察
Clinical Observation of Domestic Imatinib Mesylate Tablet in the Treatment of Chronic Myeloid Leukemia
祝文娟 1尹大伟 1李琚 1江娟1
作者信息
- 1. 池州市人民医院血液科,安徽池州 247100
- 折叠
摘要
Abstract
OBJECTIVE:To observe therapeutic efficacy and safety of domestic Imatinib mesylate tablet in the treatment of chronic myeloid leukemia(CML). METHODS:16 CML patients were selected,including 7 newly diagnosed CML patients and 9 patients diagnosed as CML more than 12 months. Imatinib mesylate tablet 400 mg,qd were used in all patients. Blood routine, bone marrow cytology,ph chromosome Evaluate efficacy,and observed peripheral blood fusion gene,Bcr-Abl/Abl gene mutation and ADR were all detected. RESULTS:After treatment,16 patients achieved complete hematologic remission (CHR);12 cases were pavtial cytogenetic response(MCyR),of which 2 cases achieved complete cytogenetic response(CCyR),2 cases were cyto-genelic remission. 15 patients'Bcr-Abl/Abl transcript levels were less than 10%,and only one case was more than 10%. No ADR difficult to tolerate was found in 16 patients. CONCLUSIONS:Domestic Imatinib mesylate tablet shows definite early therapeutic efficacy and high safety.关键词
国产/伊马替尼/慢性粒细胞白血病/疗效/安全性Key words
Domestic/Imatinib/Chronic myeloid leukemia/Therapeutic efficacy/Safety分类
医药卫生引用本文复制引用
祝文娟,尹大伟,李琚,江娟..国产甲磺酸伊马替尼片治疗慢性粒细胞白血病的临床观察[J].中国药房,2016,27(5):671-673,3.
