中国药房2016，Vol.27Issue(5)：686-688,3.DOI:10.6039/j.issn.1001-0408.2016.05.37
CD44抗原对乳腺癌患者耐药性的影响
Effects of CD44 Antigen on Drug Resistance of Breast Cancer Patients
陆佩知 1杨会张 1杜娟 1金永1
作者信息
- 1. 江苏省泗洪县分金亭医院肿瘤科,江苏泗洪 223900
- 折叠
摘要
Abstract
OBJECTIVE:To evaluate the effect of CD44 on drug resistance of breast cancer patients. METHODS:62 breast cancer patients were selected,and the expression of CD44 was detected by immunohistochemical method. Drug resistance was eval-uated by WHO criteria,and the expression of CD44 in breast tissue was observed after observation. RESULTS:There were 48 pa-tients sensitive to CD44 and 14 patients with drug resistance,with statistical significance(P<0.05). After chemotherapy,the ex-pression of CD44 in caner tissue was higher than before chemotherapy,that of patients with drug resistance was higher than pa-tients sensitive to CD44,with statistical significance(P<0.01). CONCLUSIONS:CD44 antigen is closely related to chemothera-py resistance of breast cancer,and high expression of CD44 can be used as an important indicator for breast cancer chemotherapy.关键词
CD44/乳腺癌/化疗/耐药Key words
KEYWORDS CD44/Breast cancer/Chemotherapy/Drug resistance分类
医药卫生引用本文复制引用
陆佩知,杨会张,杜娟,金永..CD44抗原对乳腺癌患者耐药性的影响[J].中国药房,2016,27(5):686-688,3.
