中国药房Issue(6)：734-736,3.DOI:10.6039/j.issn.1001-0408.2016.06.05
缬沙坦联合泼尼松治疗特发性肺间质纤维化的临床观察
Clinical Observation of Valsartan Combined with Prednisone in the Treatment of Idiopathic Pulmonary Fibro-sis
摘要
Abstract
OBJECTIVE:To observe the efficacy and safety of valsartan combined with prednisone in the treatment of idiopath-ic pulmonary fibrosis. METHODS:50 patients with idiopathic pulmonary fibrosis were randomly divided into control group and ob-servation group. Control group was orally given 0.5 mg/(kg·d)Prednisone acetate tablet in 1-4 weeks,then maintained with 0.125 mg/(kg·d)in 5-12 neeks,2-3 times a day;observation group was additionally given 80 mg Valsartan capsule,orally,once a day. The treatment course for both groups was 6 months. Pulmonary function indicators [forced vital capacity(FVC),peak expiratory flow rate (PEFR),and forced expiratory volume in one second (FEV1)],serum inflammatory factor indicators [interleukin-13(IL-13), IL-18,transforming growth factor-β1(TGF-β1)] level,matrix metalloproteinase-9(MMP-9),MMP-2 contents and the incidence of adverse reactions in 2 groups were observed. RESULTS:The total effective rate in observation group was significantly higher than control group,the difference was statistically significant(P<0.05). Before treatment,there were no significant differences in the pulmonary function indicators,serum inflammatory factor indicators,MMP-9 and MMP-2 contents between 2 groups(P>0.05);af-ter treatment,pulmonary function indicators in 2 groups were significantly higher than before,and observation group was higher than control group,MMP-9 and MMP-2 contents were significantly lower than before,and observation group was lower than con-trol group(P<0.05). And there was no significant difference in the incidence of adverse reactions between 2 groups(P>0.05). CONCLUSIONS:Valsartan combined with prednisone can significantly improve the pulmonary function of patients with idiopathic pulmonary fibrosis,and reduce the contents of serum inflammatory cytokines and matrix metalloproteinases,with good safety.关键词
特发性肺间质纤维化/缬沙坦/泼尼松/炎症因子/基质金属蛋白酶/疗效/安全性Key words
Idiopathic pulmonary fibrosis/Valsartan/Prednisone/Inflammatory factor/Matrix metalloproteinase/Efficacy/Safety分类
医药卫生引用本文复制引用
霍艳霞,王志华,李爱敏,阮昕,宁学聪..缬沙坦联合泼尼松治疗特发性肺间质纤维化的临床观察[J].中国药房,2016,(6):734-736,3.基金项目
邢台市科学技术研究与发展计划 （）
