中国药理学通报Issue(2)：149-154,155,7.DOI:10.3969/j.issn.1001-1978.2016.02.001
抗阿尔茨海默病天然产物及其药理学研究进展
Pharmacological research of natural products in the treatment of Alzheimer’ s disease
摘要
Abstract
Alzheimer’ s disease ( AD) , a central nervous system degenerative disease, is characterized by progressive cognitive impairment and memory damage. Although intensive research leads to a better understanding of AD pathology, no new medi-cines are found to prevent, delay or stop the progression of AD. Three cholinesterase inhibitors ( donepezil, rivastigmine and ga-lantamine) and an N-methyl D-aspartase NMDA receptor antag-onist, memantine have been approved in clinic for AD treat-ment, but these treatments only have modest symptomatic effects for relatively short time periods. Therefore, to find effective medicines to prevent, improve and treat AD is urgent. It is well known, the traditional Chinese medicine resources are abundant in China. Chinese medicines, including the active ingredients and compounds, have been used in dementia treatment for a long history. The review is aimed to summarize the application and related mechanisms of natural products such as huperzine A, ginsenosides, L-3-n-butylphathlide, TSG and so on in AD treat-ment.关键词
阿尔茨海默病/天然产物/石杉碱甲/银杏叶提取物/左旋丁基苯酞/二苯乙烯苷/人参皂苷Key words
Alzheimer’ s disease/natural products/huperzine A/extracts of ginkgobilobaleaves/L-3-n-butylphathlide/TSG/ginsenosides分类
医药卫生引用本文复制引用
李琳,王晓良,彭英..抗阿尔茨海默病天然产物及其药理学研究进展[J].中国药理学通报,2016,(2):149-154,155,7.基金项目
国家自然科学基金资助项目( No 81473200) （ No 81473200）
教育部新世纪优秀人才支持计划( No NECT-10-0961) （ No NECT-10-0961）
国家科技部“重大新药创制”科技重大专项( No 2012ZX09301002-004) （ No 2012ZX09301002-004）
新药作用机制研究与药效评价北京市重点实验室(No BZ0150) （No BZ0150）
