中国药理学通报Issue(2)：163-168,169,7.DOI:10.3969/j.issn.1001-1978.2016.02.004
NLRP3炎症小体在动脉粥样硬化相关细胞中作用的研究进展
Research progress of NLRP3 inflammasome in atherosclerosis-related cells
摘要
Abstract
Inflammasome, which is a large multiprotein complex in the cytosol regulating IL-1β production, plays an important role in atherosclerosis ( AS ) . To date, NLRP3 ( nucleotide-binding domain and leucine-rich repeat protein 3) inflammasome is the most widely studied type of inflammasome. This article aims to review the effects of NLRP3 inflammasome on AS-related cells ( endothelial cells, macrophages and vascular smooth mus-cle cells) to further explore the role of NLRP3 inflammasome in the progression of AS.关键词
NLRP3 炎症小体/IL-1β/动脉粥样硬化/内皮细胞/巨噬细胞/血管平滑肌细胞Key words
NLRP3 inflammasome/IL-1β/atherosclerosis/en-dothelial cells/macrophages/vascular smooth muscle cells分类
医药卫生引用本文复制引用
卞芳,金肆..NLRP3炎症小体在动脉粥样硬化相关细胞中作用的研究进展[J].中国药理学通报,2016,(2):163-168,169,7.基金项目
国家自然科学基金资助项目(No 81373413,81503072) （No 81373413,81503072）
湖北省卫生计生青年人才项目(No WJ2015Q037) （No WJ2015Q037）
