中国药理学通报Issue(2)：169-171,3.DOI:10.3969/j.issn.1001-1978.2016.02.005
FoxOs与骨质疏松
FoxOs and osteoporosis
摘要
Abstract
As one subclass of forkhead proteins, the forkhead box O ( FoxO) transcription factors take part in a series of bio-logical processes including cellular apoptosis, damaged DNA re-pair and cleavage of reactive oxygen species(ROS). Increasing evidence highlights that oxidative stress elicited by FoxOs con-tributes to imbalance of redox status in cells related to bone me-tabolism, resulting in development of the pathogenesis of osteo-porosis. This article reviews the relationship of FoxOs and osteo-porosis, which may be beneficial for the research of pathological mechanism and therapeutic strategy of osteoporosis.关键词
FoxOs/骨质疏松/氧化应激/活性氧自由基(ROS)/发病机制/防治策略Key words
FoxOs/osteoporosis/oxidative stress/reactive oxygen species ( ROS )/pathological mechanism/therapeutic strategy分类
医药卫生引用本文复制引用
李近,杨亚军,刘钰瑜..FoxOs与骨质疏松[J].中国药理学通报,2016,(2):169-171,3.基金项目
广东省科技计划资助项目(No 2012B031800225) （No 2012B031800225）
广东省教育厅特色创新项目(No 2014KTSCX084) （No 2014KTSCX084）
