中国药理学通报Issue(2)：172-176,5.DOI:10.3969/j.issn.1001-1978.2016.02.006
单克隆抗体药物的药代动力学研究进展
Progress on pharmacokinetic studies of therapeutic monoclonal antibodies
摘要
Abstract
Monoclonal antibody ( mAb ) represents a class of therapeutics experienced dramatic development over the past 30 years. Because of the tremendous differences in physicochemical and biological properties between mAbs and small molecules, the mAb therapeutics significantly differ from the chemical drugs in pharmacokinetic characteristics and underlying mechanisms. Full understanding of those characteristics and mechanisms may efficiently guide the screening and development of mAb medi-cines, and would well support their safety evaluation and clinical dosage regimen designing. This review is to summarize pharma-cokinetics and underlying mechanisms of mAbs from the aspects of absorption, distribution and elimination, as well as the ap-proaches for prediction of mAb pharmacokinetics in humans.关键词
单克隆抗体/药代动力学/吸收/分布/消除/人体药代动力学预测Key words
monoclonal antibody/pharmacokinetics/absorp-tion/distribution/elimination/prediction of human pharmacoki-netics分类
医药卫生引用本文复制引用
郭建军,王丽丽,张琪,张奥博,朱晶,赵永跃,张炳旭,卜海之..单克隆抗体药物的药代动力学研究进展[J].中国药理学通报,2016,(2):172-176,5.基金项目
苏州科学技术局姑苏创新创业领军人才基金资助项目(No XG0826) （No XG0826）
