中国药理学通报Issue(2)：223-228,6.DOI:10.3969/j.issn.1001-1978.2016.02.015
SAHA和TRAIL联合使用对乳腺癌雌激素受体阳性细胞MCF-7生长的影响
Effects of combination treatment with SAHA and TRAIL on ER positive breast cancer cell MCF-7
摘要
Abstract
Aim To investigate the effects of com-bined treatment of SAHA and TRAIL on human breast cancer ER positive cell line MCF-7 . Methods MCF-7 cells were treated with SAHA and/or TRAIL. The inhibitory rates were detected by real-time cell prolifer-ation assays. Morphology changes of MCF-7 cells were observed through time-lapse live cell imaging acquisi-tion. Results Real-time cell proliferation assays showed that the anti-tumor efficacy of SAHA was sig-nificantly enhanced in combination with TRAIL. The results of time-lapse live cell imaging acquisition dem-onstrated that, with treatment of SAHA and TRAIL, the growth inhibition of MCF-7 cells was more obvious than that of in TRAIL or SAHA treatment alone. Con-clusion The combination treatment of SAHA and TRAIL has a synergistic effect of growth inhibition on breast cancer MCF-7 cells.关键词
SAHA/TRAIL/乳腺癌/雌激素受体阳性/MCF-7/协同作用Key words
SAHA/TRAIL/breast cancer/ER posi-tive/MCF-7 cell/synergistic effects分类
医药卫生引用本文复制引用
韩翰,王敏..SAHA和TRAIL联合使用对乳腺癌雌激素受体阳性细胞MCF-7生长的影响[J].中国药理学通报,2016,(2):223-228,6.基金项目
国家自然科学基金资助项目(No 81172509) （No 81172509）
沈阳医学院科技发展基金(No 20135061) （No 20135061）
