中国药理学通报Issue(2)：285-287,288,4.DOI:10.3969/j.issn.1001-1978.2016.02.026
复方总黄酮对小鼠慢性酒精性睾丸损伤的作用研究
Protective effects of compound flavones against alcohol-induced testicular injury in mice
摘要
Abstract
Aim To study the protective effect of the compound flavones on chronic alcohol induced testicu-lar damage in mice. Methods One hundred SPF C57 BL/6 mice were randomly divided into 5 groups:normal control group, chronic alcohol group, alcohol+low-dose drug group, alcohol+high dose drug group, and drug control group. Chronic alcohol testicular inju-ry model in mice was established by intragastric admin-istration of increasing dose of alcohol every four weeks for 6 months, meanwhile compound flavone interven-tion was in process. The activity of super oxide dis-mutase( SOD) , the levels of malondialdehyde( MDA) and testosterone in testicular tissue were measured. HE staining was used to observe testicular histomorpholo-gy, and ultrastructure changes were detected by elec-tron microscope. Results In chronic alcohol group, MDA content was obviously increased, while SOD and testosterone levels were decreased compared with nor-mal control group ( P <0. 05 ) . In addition, germinal epithelium, support cells and sperm production at all levels showed degraded degeneration in chronic alcohol group. However, compound flavonoids could success-fully reverse alcohol-induced testicular damage in a dose-dependent way. Conclusion The compound of flavones may have therapeutic potential for alcohol-in-duced testicular injury through inhibiting lipid peroxi-dation and increasing the level of testosterone.关键词
复方总黄酮/酒精/睾丸/睾酮/精子发生/氧化损伤Key words
compound flavones/alcohol/testes/tes-tosterone/spermatogenesis/oxidative damage分类
医药卫生引用本文复制引用
查文良,柯志强,高卉,白育庭..复方总黄酮对小鼠慢性酒精性睾丸损伤的作用研究[J].中国药理学通报,2016,(2):285-287,288,4.基金项目
湖北省教育厅青年项目( No Q20152803) （ No Q20152803）
湖北科技学院科研项目(No zx1205) （No zx1205）
