中国医学创新Issue(3)：22-24,3.DOI:10.3969/j.issn.1674-4985.2016.03.007
不同强度的运动对去卵巢大鼠骨质疏松症的骨代谢机制的研究
The Research on Different Load Exercise to the Bone Mechanism of Osteoporosis in Ovariectomized Rats
摘要
Abstract
Objective: To explore the mechanism of exercise in treating osteoporosis by detecting the osteoprotegrin(OPG),receptor activator of nuclear factor kappa B ligand (RANKL)and insuline growth factor-1(IGF-1).Method: Female Sprague-Dawley rats were randomly divided into normal control group, sham-operated group,model group,30 min exercise group and 60 min exercise group, and the exercise group continuous training 8 weeks. The rats were executed, the serum were tested.Result:After 8 weeks, compared with the control group,the weight of the model group and 30 min exercise group increased raised significantly (P<0.05). Compared with the control group, the expression of OPG and IGF-1 decreased much significantly in the model group, and the RANKL increased apparently(P<0.01). The OPG and IGF-1 in 60 min exercise group increased much significantly compared with that of the model group (P<0.01), the OPG also increased in the 30 min exercise group (P<0.05).Conclusion:Exercise can regulate OPG and RANKL expression in osteoclast differentiation pathway to ovarian rats, IGF-1 may be involved in the regulation of OPG. Exercise can prevent and treat osteoporosis in ovariectomized rats.关键词
骨质疏松/运动/OPG/RANKL/IGF-1Key words
Ovariectomized rats/Exercise/OPG/RANKL/IGF-1引用本文复制引用
王士冲,常青,郑帅,杨西雨,刘亚,钟卫权..不同强度的运动对去卵巢大鼠骨质疏松症的骨代谢机制的研究[J].中国医学创新,2016,(3):22-24,3.基金项目
国家级大学生创新训练项目 （）
