中国医学创新Issue(4)：23-26,4.DOI:10.3969/j.issn.1674-4985.2016.04.007
降钙素原在慢性阻塞性肺疾病急性加重期的临床研究
Assessment of Antibiotic Prescribing Based on Serum Procalcitonin (PCT) Level for Acute Exacerbation of Chronic Obstructive Pulmonary Disease
摘要
Abstract
Objective: To investigate appropriateness of antibiotic prescribing based on procalcitonin (PCT) level for acute exacerbation of chronic obstructive pulmonary disease (AECOPD).Method: 200 AECOPD patients were selected in our hospital from February 2014 to March 2015, and they were randomly divided into observation group and control group according to random number table method, 100 cases in each group. In the observation group, antibiotic prescribing for different durations of therapy (admission day, 5, 7, and 10 days) was based on the serum PCT level, if the PCT≥0.25 μg/L, antibiotics was used, the PCT<0.25 μg/L, didn’t use or stop using antibiotics. In the control group, antibiotic was based on clinician’s experience and patient’s symptoms. Antibiotic utilization and its times, duration of therapy, hospital costs, clinical efficiency, invasive mechanical ventilation rate, recurrent infection and mortality between the two groups were compared.Result: In the observation group, antibiotic usage rate, average usage time, hospital stay time, and hospital costs was respectively 66.00%, (9.48±1.03) days, (13.12±2.53) days, (6716.63±436.35) yuan, which was significantly lower than that of the control group, the differences were statistically significant (P<0.01), however, the clinical efficiency, invasive mechanical ventilation rate, and mortality had no significant difference (P>0.05). In addition, recurrent infection rate of the observation group was 1.00%, which was significantly lower than that of the control group (P<0.01). The WBC count and CRP concentration had no significant difference between the two groups after treatment (P>0.05). Conclusion: Antibiotic prescribing based on serum PCT levels is relevant to reduce antibiotic usage for AECOPD patients, as well as shorten duration of therapy, it is worthy of using PCT level as guidelines for antibiotic prescribing.关键词
降钙素原/慢性阻塞性肺疾病急性加重期/抗生素Key words
Procalcitonin/Acute exacerbation of chronic obstructive pulmonary disease/Antibiotics引用本文复制引用
梁旭满,陈永钢,梁知锐..降钙素原在慢性阻塞性肺疾病急性加重期的临床研究[J].中国医学创新,2016,(4):23-26,4.基金项目
阳江市科技计划项目 （）
