摘要
Abstract
Objective:To investigate the influence of the drinking in cardiovascular disease mortality (CVDM) and all-cause mortality(ACM) risk in patients with coronary heart disease,analyze whether had synergistic effect in the risk of the CVDM and ACM for the drinking and coronary heart disease.Method:5000 patients with coronary heart disease admitted to our hospital from January 2001 to December 2011 were selected. The demographic information, drinking and personal history of disease data were collected,the CVDM and ACM of the patients were followed up and recorded.The influence of drinking indexes in CVDM and ACM risk in patients with coronary heart disease were analyzed using the COX proportional hazards model.Result:The average follow-up time was 5.7 years,totally follow-up was 46 157.9 person years.ACM 1257 people,including 655 cases of CDVM in the time of follow-up period.The results of the COX proportional hazards model showed that:(1)Drinking could increase the risk of CVDM and ACM in coronary heart disease patients(RR=1.235 and 1.392).(2)In the aspect of the CVDM and ACM risk:daily drinking amount >10 branch was higher than 1 branch to 10 branches,the cumulative amount of drinking≥20 package year was higher than the 0.1-19 package year,drinking duration >35 years was higher than 1 year to 35 years,started drinking age≤20 years old was higher than > 20 years old,the differences were statistically significant(P<0.05).(3)When the SBP≥160 mm Hg,DBP≥100 mm Hg, PP≥70 mm Hg or≥level 2 coronary heart disease and the cumulative amount of drinking≥20 packages year, the CVDM risk respectively were(RR=2.352,2.633,2.254,2.336);ACM risk respectively were (RR=3.092, 2.346,1.936,2.018).Conclusion:Drinking can increase the risk of CVDM and ACM in coronary heart disease patients,and has a dose response relationship.Blood pressure and drinking elevated at the same time can further increase the risk.关键词
冠心病高血压/饮酒/心血管疾病死亡/全因死亡/流行病学调查Key words
Coronary heart disease/Drinking/Cardiovascular disease mortality/All-cause mortality/Epidemiological investigation
