中国医学创新Issue(5)：77-79,80,4.DOI:10.3969/j.issn.1674-4985.2016.05.021
结肠癌与直肠癌在癌变分子机制及信号通路方面的对比
Comparison of Molecular Mechanism and Signal Pathway of Colon Cancer and Rectal Cancer
邓艳 1柯晴1
作者信息
- 1. 南宁市第二人民医院 广西 南宁 530031
- 折叠
摘要
Abstract
Objective:To explore the similarities and differences between colon cancer and rectal cancer in oncogenesis molecular mechanism.Method:Each 30 cases of colon cancer and rectal cancer tissue specimens in our hospital from January 2013 to December 2014 were used for gene mutation detection,each eight fresh tissue specimens of colon cancer and rectal cancer were used for signaling pathways detection.The positive rate of protein expression and the signaling pathways of different specimens were compared.Result:The differences in protein expression of APC,Wnt-1 and p53 gene between the two groups were not statistically significant(P>0.05). The positive rates of PSM2 and MLH1 protein expression in the rectal cancer group were higher than those in the colon cancer group,the differences were statistically significant(P<0.01).The positive rates of MSH2 and MSH6 protein expression in the colon cancer group were higher than those in the rectal cancer group,the differences were statistically significant(P<0.05).The mutation rate of K-ras in the colon cancer group was higher than that in the rectal cancer group,the difference was statistically significant(P=0.038).The common signal pathways of colon cancer and rectal cancer were metabolic pathway,Wnt/β-catenin,pathway of vascular smooth muscle contraction,closely connected pathway and cell cycle pathway.Most differential genes related to these pathways expressed.Axon guidance pathway appeared only in rectal cancer.Signaling pathway of p53 gene and drug metabolizing-cytochrome P450 pathway most appeared in colon cancer.Conclusion:Colon and rectal cancer have common and personal molecular mechanism.Their common manifestations show that Wnt signaling pathway, mutant p53 protein and APC protein play an important role in carcinogenesis process.Their individualitys show that presence of large mismatch repair gene mutations that cause protein loss mainly consists of PSM2 and MLH1 in colon cancer,but it mainly consists of MSH2 and MSH6 in rectal cancer.关键词
结肠癌/直肠癌/分子机制Key words
Colon cancer/Rectal cancer/Molecular mechanism引用本文复制引用
邓艳,柯晴..结肠癌与直肠癌在癌变分子机制及信号通路方面的对比[J].中国医学创新,2016,(5):77-79,80,4.
