中国医学创新Issue(6)：15-17,3.DOI:10.3969/j.issn.1674-4985.2016.06.005
黄芪多糖对糖尿病小鼠血清胰岛素样生长因子-1的影响
The Impact of Astragalus Polysaccharides on Serum Levels of Insulin-Like Growth Factor-1 in Diabetic Mice
摘要
Abstract
Objective:To study the influence of astragalus polysaccharides(APS) on insulin-like growth factor(IGF-1) in diabetic mice.Method:A total of 60 mice were randomly divided into three groups, blank group,APS group and control group,each group had 20 cases.The APS group and the control group were fed with diets high in saturated fat and peritoneal injected small dose of Streptozotocin for DM mice model.After modeling, the APS group was intragastrically administrated to APS for 8 weeks, while physiological saline was used as control. The change of the serum level of IGF-1, ICAM-1, VCAM-1 and MCP-1 were observed by enzyme-linked immunosorbent (ELISA),and these indicators were used to evaluate the function of APS.Result:After treatment, the serum level of ICAM-1, VCAM-1 and MCP-1 were significantly declined, while the serum level of IGF-1 increased significantly, these changes were significant differences compared with the control group (P<0.05). Conclusion: Short-term treatment of APS can improve the level of serum IGF-1 in DM mice, accompanied by the decline of inflammatory indexes such as ICAM-1,VCAM-1.关键词
黄芪多糖/胰岛素样生长因子-1/糖尿病/动脉粥样硬化Key words
Astragalus polysaccharides/IGF-1/Diabetes mellitus/Artherosclerosis引用本文复制引用
刘毅,江腾春,李志樑,傅强..黄芪多糖对糖尿病小鼠血清胰岛素样生长因子-1的影响[J].中国医学创新,2016,(6):15-17,3.基金项目
广东省中医药局科研课题面上项目 （）
