摘要
Abstract
Objective To explore clinical curative effect of interferon alpha-2b combined with thymosin alpha 1 in treatment of chronic hepatitis B.Methods160 patients with chronic hepatitis B were randomly allocated to the control group and the observation group. The control group was treated by interferon alpha-2b while the observation group was received thymosin alpha 1 at the basis of the treatment in the control group. Curative effects of two groups were compared.ResultsAST and ALT normalization rate of 6 months after treatment of the observation group were 45% and 50% respectively and those of the control group respectively were 18.8% and 17.5% respectively (P<0.05). Negative rates of HBsAg of 6, 9 and 12 months after treatment of the observation group were 21.3%, 3.2% and 32.5% respectively while those of the control group were 5.0%, 12.5% and 15.0% respectively (P<0.05). In addition, negative rates of HBV DNA of 6, 9 and 12 months after treatment of the observation group were 58.8%, 62.5% and 62.5% respectively while those of the control group were 31.3%, 36.3% and 36.3% respectively (P<0.05). QOL scores of 6 and 12 months after treatment of two groups were both significantly better than those before treatment (P<0.05). The scores of physiological and social relations of the observation group were (63.1±10.2) score and (60.4±12.7) score respectively, significantly higher than those of the control group, and the differences had statistical significance (P<0.05). The scores of physical, psychological and social relationship of the observation group were (65.4±11.1)score, (64.6±13.5)score and (62.4±12.6)score respectively, significantly higher than those of the control group (P<0.05). There was no statistical significance when incidences of adverse reactions in two groups were compared (P>0.05).Conclusion Interferon alpha-2b combined with thymosin alpha 1 in treatment of patients with chronic hepatitis B can effectively remove HBV, improve patients' immunity and control the occurrence of adverse reactions. It has an accurate curative effect, worthy of clinical promotion and application.关键词
干扰素α-2b/α1胸腺肽/慢性乙型肝炎/疗效Key words
Interferon alpha-2b/Thymosin alpha 1/Chronic hepatitis B/Curative effect分类
医药卫生
