摘要
Abstract
Objective To study the clinical treatment effect of different administration time of tirofiban hydrochloride on antithrombotic therap in patients with acute ST-segment elevation myocardial infarction. Methods 80 patients with acute ST-segment elevation myocardial infarction, who were selected from Janury to December 2014, were randomly divided into preoperative treatment group (40 cases) and intraoperative treatment group (40 cases). Patients in preoperative treatment group were treated with tirofiban hydrochloride before coronary angiography, while patients in intraoperative treatment group were treated with coronary intervention therapy meanwhile tirofiban hydrochloride. To comparative analyze the treatment effect between the two groups, to compare the indexes of TIMI frame count, 3 grade rate of Blush classification, peak concentration of creatine kinase isoenzyme (CKMB), postoperative 90min ST decrease amplitude and so on. Results TIMI frame count in preoperative treatment group(22.3±7.9) was significantly lower than which in intraoperative treatment group(32.4±4.1), postoperative 90min ST decrease amplitude in preoperative treatment group was greater than which in intraoperative treatment group, peak concentration of CKMB in preoperative treatment group(251.2±40.1) was obviously lower than which in intraoperative treatment group(364.9±57.1), 3 grade rate of Blush classification in preoperative treatment group was obviously higher than which in intraoperative treatment group,the differences were statically significant(P<0.05). Conclusion The comparison result between the two groups showed that, tirofiban hydrochloride in the treatment of patients with acute ST-segment elevation myocardial infarction before coronary intervention therapy, has significantly improved the treatment effect of coronary flow, is worthy of clinical popularization.关键词
盐酸替罗非班/不同时间/急性ST段抬高型心肌梗死Key words
Tirofiban hydrochloride/Different time/Acute ST-segment elevation myocardial infarction分类
医药卫生
