磁共振成像Issue(1)：1-5,5.DOI:10.12015/issn.1674-8034.2016.01.001
基于体素形态学测量技术对高原地区正常成人脑结构的研究
Study of brain structure in nomal plateau area adult with voxel-based morphometry
摘要
Abstract
Objective:The aim of the study was to investigate the brain structure volumes alterations in born and raised high altitude (HA) (>3000 m) normal adult by usingvoxel-basedmorphometrymethod(VBM).Materials and Methods:Two groups of adults participated in the study, including an HA group [8 males and 8 females, mean age=(21.81±2.07) years] and an age-and education-matched sea level (SL) group [7 males and 13 females, mean age=(21.85±1.90) years]. 3D-T1 structural images of all subjects who were underwent the whole brain scan were acquired. Then we used the VBM method to compare the whole brain GM and WM images differences between HA group and SL group. Results:HA acclimatization (vs. SL) showed increased gray matter volume in the left posterior cingulate, the left superior temporal gyrus,decreased GM volumes was found in the right insular lobe in highland group and we also found increased WM volumes in left thalamus, the right superior frontal gyrus, the lentiform nucleus, the left occipital lobe. Conclusions:The VBM method was applied to the analysis of the magnetic resonance structural images and it could objectively display the volume changes of specific brain areas in HA group and could get us a comprehensive evaluation of the impact of altitude hypoxia on brain structure.关键词
脑/人体测量术/高原/磁共振成像Key words
Brain/Anthropometry/Altitude/Magneticresonanceimaging分类
医药卫生引用本文复制引用
李超伟,鲍海华,孔德民,李伟霞,员强..基于体素形态学测量技术对高原地区正常成人脑结构的研究[J].磁共振成像,2016,(1):1-5,5.基金项目
国家自然科学基金(编号81060117)；青海省科技厅国际合作项目(编号2012-H-807)ACKNOWLEDGMENTS National Natural Science Foundation of China(No.81060117). International cooperation project of science and Technology Department of Qinghai Province (No.2012-H-807) （编号81060117）
