磁共振成像Issue(1)：34-39,6.DOI:10.12015/issn.1674-8034.2016.01.007
DKI技术在肝外胆管癌分级中的应用价值
Application value of DKI in grading of extrahepatic cholangiocarcinoma
摘要
Abstract
Objective:To evaluate the application value of diffusion kurtosis imaging (DKI) based D, K parameters in grading extrahepatic cholangiocarcinoma (EHCC) andcomparetheirdiagnosticpotential.Materials and Methods:Thirty-five consecutive patients surgically resected and pathologically confirmed EHCC were included in this study. All patients underwent upper abdomen magnetic resonance imaging, including traditional magnetic resonance imaging and diffusion kurtosis imaging. The DKI derived parameters D, K were calculated by using post-processing software. Compared with histologic grade (well-differentiated, moderately differentiated and poorly differentiated adenocarcinoma), evaluating the association and compare the diagnostic potential of parameters by using receiver operating characteristic (ROC) analysis. Results:Thirty-five cases of EHCC include:gradeⅠ(well-differentiated adenocarcinoma) 11 cases, gradeⅡ(moderately differentiated adenocarcinoma) 11 cases and gradeⅢ(poorly differentiated adenocarcinoma) 13 cases. GradeⅠgroup lesions parameter D, K values were (1.56±0.08) ×10–3 mm2/s, 0.38±0.07. GradeⅡgroup were (1.47±0.09) ×10–3 mm2/s, 0.51±0.08. GradeⅢgroup were (1.39±0.07) ×10–3 mm2/s, 0.66±0.08. D and K values were significantly different in well, moderately and poorly differentiated adenocarcinoma (P<0.001, <0.001). With the reduction of histological differentiation degree, D value decreased, while K value increased (r=0.672, 0.848). ROC analysis demonstrated a higher area under the ROC curve value for K than for D for differentiating different pathological grade of EHCC (0.860 VS 0.951). Conclusions: K value of EHCC showed significantly diagnostic performance in differentiating different grade EHCC, and are helpful of pathologic degree in preoperative diagnosis.关键词
胆管上皮癌/胆管,肝外/磁共振成像/病理学Key words
Cholangiocarcinoma/Bileducts,extrahepatic/Magneticresonance imaging/Pathology分类
医药卫生引用本文复制引用
徐蒙莱,邢春华,陈宏伟,崔兴宇..DKI技术在肝外胆管癌分级中的应用价值[J].磁共振成像,2016,(1):34-39,6.基金项目
江苏省自然科学基金面上研究项目(编号BK2012541)ACKNOWLEDGMENTS This project was supported by Jiangsu Province Nature Science Foundation (No. BK2012541) （编号BK2012541）
