海南医学院学报Issue(8)：747-750,4.DOI:10.13210/j.cnki.jhmu.20160113.002
急性心肌梗死患者血清中 miRNAs 含量检测对病变程度及预后情况的判断价值
Judgment value of serum miRNAs content detection for degree of lesions and prognosis of patients with acute myocardial infarction
摘要
Abstract
[ABSTRACT]Objective:To study the judgment value of serum miRNAs contents for degree of lesions and prognosis of patients with acute myocardial infarction.Methods:A total of 52 cases of patients with acute myocardial infarction were select-ed as AMI group,52 cases of healthy volunteers were selected as control group,and serum was collected to detect the contents of miRNAs,inflammatory factors and protease molecules.Results:Serum miR-1,miR-22,miR133a and miR133b contents in AMI group were higher than those in control group,while miR-147,miR-214 and miR328 contents were lower than those in control group;the more the number of coronary lesions in patients with AMI,the higher the contents of serum miR-1,miR-22,miR133a and miR133b,and the lower the contents of miR-147,miR-214 and miR328;serum hs-CRP,TNF-α,MCP-1, IL-6 and IL-18 contents in AMI group were significantly higher than those in control group;results of the correlation analysis between inflammatory factor contents and miRNAs contents were as follows:hs-CRP,TNF-α,MCP-1,IL-6,IL-18,MMP1, MMP2,MMP3, MMP8, MMP9, MMP14 and ADAMTS-1 contents were negatively correlated with miR-1, miR-22, miR133a and miR133b contents,and positively correlated with miR-147,miR-214 and miR328 contents.Conclusion:Serum miR-1,miR-22,miR133a,miR133b,miR-147,miR-214 and miR328 contents are abnormal in patients with acute myocardial infarction,and miRNAs may be involved in the occurrence and development of the disease through regulating the expression of inflammatory factors and protease molecules.关键词
急性心肌梗死/microRNA/炎性因子/基质金属蛋白酶Key words
Acute myocardial infarction/microRNA/Inflammatory factors/Matrix metalloproteinase分类
医药卫生引用本文复制引用
林秋伟,林燕仙,朱秀龙,张灿..急性心肌梗死患者血清中 miRNAs 含量检测对病变程度及预后情况的判断价值[J].海南医学院学报,2016,(8):747-750,4.基金项目
广州中医药大学第一临床医学院2015年学院教育教学课题(20151503) （20151503）
