海南医学院学报Issue(8)：758-761,764,5.DOI:10.13210/j.cnki.jhmu.20160125.053
促肝细胞生长素联合恩替卡韦治疗对慢性重型肝炎血清学指标及病情转归的影响
Effect of hepatocyte growth-promoting factor combined with entecavir therapy on serological indicators and outcome of chronic severe hepatitis
摘要
Abstract
[ABSTRACT]Objective:To analyze the effect of hepatocyte growth-promoting factor combined with entecavir therapy on serological indicators and outcome of chronic severe hepatitis.Methods:A total of 1 10 patients with chronic severe hepatitis who were treated in our hospital and the Third People's Hospital of Shenzhen were enrolled for study and divided into control group with 52 cases who received conventional antiviral therapy and observation group with 58 cases who received antiviral drug combined with hepatocyte growth-promoting factor therapy.Differences in inflammation-related indicators,serum biochemical indicators,interleukin (IL)-10,IL-12,interferon-γand HBV DNA contents as well as COX-2 metabolite expression levels be-tween two groups were compared.Results:Serum white blood cell,PMN,C-reactive protein,endotoxin and PCT levels in ob-servation group after treatment were significantly lower than those in control group (P <0.05);serum total bilirubin,alpha fe-tal protein,blood urea nitrogen and creatinine levels in observation group after treatment were lower than those in control group,while levels of albumin and cholinesterase were higher than those in control group (P <0.05);serum IL-10,IL-12,in-terferon-γand HBV DNA contents in observation group after treatment were lower than those in control group (P <0.05);se-rum thromboxaneB2 and ratio of thromboxaneB2/6-keto-prostaglandin1αlevels in observation group after treatment were lower than those in control group,while 6-keto-prostaglandin1αlevel was higher than that in control group (P <0.05).Conclusions:Antiviral drugs combined with hepatocyte growth-promoting factor therapy for patients with chronic severe hepatitis can effec-tively improve liver function and inhibit the activity of hepatitis B virus replication,with an active significance in both relieving the disease and improving the prognosis.关键词
慢性重型肝炎/恩替卡韦/促肝细胞生长素Key words
Chronic severe hepatitis/Entecavir/Hepatocyte growth-promoting factor分类
医药卫生引用本文复制引用
杨襄蓉,刘艳..促肝细胞生长素联合恩替卡韦治疗对慢性重型肝炎血清学指标及病情转归的影响[J].海南医学院学报,2016,(8):758-761,764,5.基金项目
广东省医学科研课题项目(A2011280) （A2011280）
