海南医学院学报Issue(8)：803-806,4.DOI:10.13210/j.cnki.jhmu.20160125.016
胃癌根治术围手术期应用ω-3多不饱和脂肪酸的临床疗效研究
Cl inical efficacy of appl ication of ω-3 polyunsaturated fatty acids in perioperative period of radical operation for gastric cancer
摘要
Abstract
[ABSTRACT]Objective:To study the regulating effect of application of ω-3 polyunsaturated fatty acids in perioperative pe-riod of radical surgery for gastric cancer on patients’nutritional status,inflammatory response and immune function.Methods:A total of 86 cases of patients receiving radical operation for gastric cancer in our hospital were selected and randomly divided into two groups.ω-3 PUFAs group received ω-3 polyunsaturated fatty acids combined with conventional intravenous nutritional support and control group only received conventional intravenous nutritional support.Serum nutrition indicators of two groups were detected before and after surgery,and inflammation indicators in serum as well as immune molecules in tumor tissue of two groups were detected after surgery.Results:At day 1 before operation and day 3 after operation,serum RBP,PA,RTF, PEPT1 and ghrelin contents of ω-3 PUFAs group were significantly higher than those of control group;at day 3 after opera-tion,serum CC1 6,α-MSH and HSP70 contents of ω-3 PUFAs group were significantly higher than those of control group, while LBP and sCD14 contents were significantly lower than those of control group;B7-H1,B7-H4,CD1 57 and CD133 con-tents in tumor tissue of ω-3 PUFAs group were significantly lower than those of control group,while CD1 1c content was sig-nificantly higher than that of control group.Conclusion:Application of ω-3 polyunsaturated fatty acids in perioperative period of radical operation for gastric cancer can improve patients’nutritional status,reduce postoperative inflammatory response caused by surgical trauma and regulate the expression of immune molecules in tumor tissue.关键词
胃癌/ω-3 多不饱和脂肪酸/营养状况/炎症反应/免疫应答Key words
Gastric cancer/ω-3 polyunsaturated fatty acids/Nutritional status/Inflammatory response/Immune re-sponse分类
医药卫生引用本文复制引用
李伟学,邬善敏,曾涛..胃癌根治术围手术期应用ω-3多不饱和脂肪酸的临床疗效研究[J].海南医学院学报,2016,(8):803-806,4.基金项目
湖北省教育厅科学研究计划资助项目(Q20151909) （Q20151909）
