检验医学与临床Issue(3)：302-303,306,3.DOI:10.3969/j.issn.1672-9455.2016.03.006
促红素对腺嘌呤致慢性肾衰竭大鼠血清脑源性神经营养因子的影响
Regulation effect of EPO on srume BDNF level in rats with CRF
摘要
Abstract
Objective To explore the regulation effect of erythropoietin (EPO) on serume brain‐derived neuro‐trophic Factor (BDNF) level in rats with chronic renal failure .Methods 50 SD rats were divided into group A(con‐trol normal group) ,group B(NS intervention CFR model) ,group C (EPO 150 IU /kg/d treatment CRF model) and group D (EPO 450 IU /kg/d treatment CRF model) .HGB ,BNU ,SCr and serume BDNF levels were assayed . Results (1)Compared with control group ,BUN and Scr were significantly increased ,serume BDNF level and HGB were decreased in the CRF model groups(P< 0 .05) ,which indicated the successful establishment of CRF rats model . Compared with group B ,serume BDNF level and HGB were significantly increased in group C and group D .Group C and Group D had significant difference in BDNF expression .Conclusion The serume BDNF level were decreased in CRF rats ,EPO can up‐regulate serume BDNF expression .关键词
促红素/肾衰模型/抑郁/脑源性神经营养因子Key words
erythropoietin/chronic renal failure model/depression/brain-derived neurotrophic factor引用本文复制引用
李凡,李琦晖,熊维建,王晓磊,王开振,任炯,方蕾..促红素对腺嘌呤致慢性肾衰竭大鼠血清脑源性神经营养因子的影响[J].检验医学与临床,2016,(3):302-303,306,3.基金项目
重庆市卫计委面上项目（2013-02-084）。 （）
