检验医学与临床Issue(3)：336-337,340,3.DOI:10.3969/j.issn.1672-9455.2016.03.019
以3倍正常上限值为cut off值评价血清脂肪酶和淀粉酶对急性胰腺炎的诊断价值
The value of lipase and amylase in diagnosising the acute pancreatitis by using 3 times normal upper limit for the cut off value
摘要
Abstract
Objective To explore the preferred laboratory index for acute pancreatitis by comparing the sensi‐tivity and specificity of serum lipase and amylase .Methods From January 2013 to June 2014 in our hospital ,data were collected on 381 patients with acute generalised or upper abdominal pain and initial raised serum lipase and/or amylase values .253 cases of patients(66 .4% ) presented with abdominal conditions other than AP and 128 had AP .In addition ,80 cases of healthy people were selected as control group .Sensitivity and specificity for both enzymes for the diagnosis of AP were calculated using the cut‐off of three times the upper limit of normal .The analytes were meas‐ured using a Johnson Vitros 350 system .Results Lipase displayed a sensitivity of 91 .4% for AP ,against 60 .2% for amylase .Specificity was 93 .3% for lipase and 92 .9% for amylase .Combined detection with lipase and amylase had a sensitivity of 93 .8% and there were no significant difference between it and the single detection of LPS that sensitivi‐ty was 91 .4% .Conclusion Serum Lipase was the first selective method for laboratory examination of acute pancrea‐titis that was better than the single detection of serum amylase and combined detection and had higher sensitivity and Specificity .Morever ,it could reduce the dependence of expensive imaging examination and radiation .关键词
急性胰腺炎/淀粉酶/脂肪酶/敏感性/特异性Key words
acute pancreatitis/serum amylase/serum lipase/sensitivity/specificity引用本文复制引用
郭静,张双双,牛国平..以3倍正常上限值为cut off值评价血清脂肪酶和淀粉酶对急性胰腺炎的诊断价值[J].检验医学与临床,2016,(3):336-337,340,3.基金项目
江苏省徐州市中心医院博士（硕士）创新团队科技项目（xzs2012084）。 （）
