检验医学与临床Issue(3)：341-343,346,4.DOI:10.3969/j.issn.1672-9455.2016.03.021
妊娠期女性血浆抗凝血酶Ⅲ和 D-二聚体参考区间的建立
Establishing reference intervals of plasma antithrombin Ⅲ and D-dimer in healthy pregnant women
邓群英 1张宏2
作者信息
- 1. 南京军区鼓浪屿疗养院检验科，福建厦门 361002
- 2. 苏州大学附属第二医院检验科，江苏苏州 215004
- 折叠
摘要
Abstract
Objective To establish our lab′s reference intervals of plasma antithrombin Ⅲ and D‐dimer in dif‐ferent gestational periods of healthy pregnant women .Methods 2 850 pregnant women within different gestational periods and 260 non‐pregnant women were enrolled .The antithrombin Ⅲ (AT‐ Ⅲ ) and D‐dimer(D‐D) were detected by STA‐R evolution automatic coagulation analyzer and original reagents .According to CLSI guideline C28‐A3 ,our lab′s reference intervals were established .Results The reference intervals of plasma antithrombin Ⅲ and D‐dimer in healthy non‐pregnant women were 84 .7% - 123 .3% ,≤ 0 .52 μg/mL ,respectively .The reference intervals of plasma AT‐ Ⅲ at gestational weeks ≤ 13 ,> 13 - 27 ,> 27 were 81 .8% - 115 .8% ,77 .7% - 112 .1% and 68 .1% - 113 .1% , respectively .The reference ranges of D‐dimer concentration were ≤ 0 .75 μg/mL ,≤ 1 .04 μg/mL ,≤ 2 .14 μg /mL ,≤3 .24 μg/mL in group of ≤ 13 weeks ,> 13 - 20 weeks ,> 20 - 27 weeks and > 27 weeks ,respectively .Conclusion The reference values of plasma AT‐ Ⅲ and D‐dimer are determined for each gestational period of pregnancy in our lab ,which may assist clinicians in making accurate clinical evaluation of coagulation ,anticoagulation and fibrinolysis function for pregnancy women .关键词
妊娠/抗凝血酶/D-二聚体/参考区间Key words
pregnancy/antithrombin/D-dimer/reference interval引用本文复制引用
邓群英,张宏..妊娠期女性血浆抗凝血酶Ⅲ和 D-二聚体参考区间的建立[J].检验医学与临床,2016,(3):341-343,346,4.
