检验医学与临床Issue(3)：352-354,3.DOI:10.3969/j.issn.1672-9455.2016.03.025
中性粒细胞 CD64对血液疾病患者发生细菌感染的诊断效果
Effect of CD64 on the diagnosis of bacterial infection in patients with hematological diseases
杨志峰 1聂海英 2李焱 1李慧娟1
作者信息
- 1. 河北省邯郸市第一医院 血液内科 056002
- 2. 河北省邯郸市第一医院 消化内科 056002
- 折叠
摘要
Abstract
Objective To explore the effect of CD64 in the diagnosis of bacterial infection in patients with he‐matological diseases .Methods 55 cases of patients with hematological disease and 51 cases of patients without hema‐tological disease were divided into blood disease infection group (39 cases) ,blood disease non infection group (16 ca‐ses) and non blood disease infection group (36 cases) and non blood disease in non infection group (15 cases)due to the occurrence of bacterial infection .CD64 ,calcitonin peptide (PCT ) ,C‐reactive protein (CRP) and white blood cell count were all detected ,and receiver operating characteristic curve(ROC) was established that ,calculated the sensi‐tivity and specificity .Results CD64 positive index ,PCT and CRP levels in Blood disease infection group were signifi‐cantly higher than those in blood disease of non infection group and the difference had statistical significance (P<0 .05) ,while white blood cell count had no statistical significance between them (P> 0 .05) .The CD64 positive in‐dex ,PCT level ,CRP level and the number of white blood cell count were significantly higher than those in non infec‐ted group and the difference was statistically significant (P< 0 .05) .CD64 positive index of blood disease group under ROC curve was 0 .973 ,in addition ,95% CI ,sensitivity and specificity were respectively 0 .727 - 0 .998 ,0 .973 and 0 .947 ;CD64 positive index of ROC curve area in non hematological disease group was 0 .942 and 95% CI ,sensitivity and specificity were respectively 0 .853 - 0 .984 ,0 .894 and 0 .863 .There was no significant difference between CD64 positive index ,PCT level ,CRP level and the number of white blood cell count in malignant and non malignant hema‐tological diseases(P> 0 .05) .Conclusion CD64 can be used as a diagnostic indicator of bacterial infection in patients with hematological diseases and it has important clinical significance for early diagnosis and treatment of bacterial in‐fections in patients with hematologic diseases .关键词
CD64/血液/细菌感染/诊断Key words
CD64/blood/bacterial infection/diagnosis引用本文复制引用
杨志峰,聂海英,李焱,李慧娟..中性粒细胞 CD64对血液疾病患者发生细菌感染的诊断效果[J].检验医学与临床,2016,(3):352-354,3.
