林产化学与工业Issue(1)：61-69,9.DOI:10.3969/j.issn.0253-2417.2016.01.009
2-取代酰氨基-5-（α-龙脑烯醛基）-1,3,4-噻二唑化合物的合成及抑菌活性
Synthesis and Antifungal Activities of 2-Sustituted Acylamino-5-(α-campholenic aldehyde)-based-1,3,4-thiadiazole Compounds
摘要
Abstract
α-Campholenic aldehyde was prepared by the epoxidation and catalytic isomerization ofα-pinene. Then,α-campholenic aldehyde-based thiadiazole was prepared by the cyclization reaction of α-campholenic aldehyde-based thiosemicarbazone, which was obtained by the reaction of thiosemicarbazide withα-campholenic aldehyde. Finally,twelve novel 2-sustituted acylamino-5-(α-campholenic aldehyde )-based-1, 3, 4-thiadiazole compounds ( 6a- 6l ) were synthesized by the N-acylation reactions ofα-campholenic aldehyde-based thiadiazole with a series of acyl chlorides. The target compounds were characterized by FT-IR, 1H NMR,13C NMR, and ESI-MS. Antifungal activity test showed that, at the concentration of 50 mg/L, the target compounds exhibited different antifungal activities against the five tested fungi. Some of them exhibited antifungal activities were close to or even better than the commercial azoxystrobin used as positive control in this study. Among them,in which compound 6j had an inhibition rate of 94. 4% against Fusarium graminearum,and compound 6h had an inhibition rate of 97. 7% against Physalospora piricola.关键词
α-蒎烯/α-龙脑烯醛/酰胺/1 ,3 ,4-噻二唑/合成/抑菌活性Key words
α-pinene/α-campholenic aldehyde/amide/1,3,4-thiadiazole/synthesis/antifungal activity分类
化学化工引用本文复制引用
黄铎云,段文贵,林桂汕,白雪,肖昊,杨章旗..2-取代酰氨基-5-（α-龙脑烯醛基）-1,3,4-噻二唑化合物的合成及抑菌活性[J].林产化学与工业,2016,(1):61-69,9.基金项目
国家自然科学基金资助项目(31260164) （31260164）
八桂学者专项资助(无编号) （无编号）
