临床小儿外科杂志Issue(1)：23-25,45,4.DOI:10.3969/j.issn.1671-6353.2016.01.007
巨细胞病毒感染与胆道闭锁 Kasai 手术预后的关系
Relationship between cytomegalovirus infection and prognosis of biliary atresia after kasai operation
摘要
Abstract
Objetive To investigate the relationship between cytomegalovirus infection and prognosis of biliary atresia.Methods A retrospective analysis was made on 87 cases of biliary atresia from Aug.2014 to Jan.2013.According to the test results of cytomegalovirus-IgMantibody,all the cases were divided into negative group (55 cases)and positive group (32 cases).Results Comparing the two groups,there was no significant difference in age (99.75 ±31.71 d ,101.34 ±33.70 d,P =0.830);or in TBILs (180.42 ±89.94 μmol/L, 191.81 ±91.48 μmol/L,P =0.58).According to Ohkuma Y the pathological results of liver biopsies were gra-ded from Ⅰ to Ⅳ.In negative group :22cases were classified into Grade Ⅰ,18 cases into GradeⅡ,11 cases into Grade Ⅲ,4 cases into Grade Ⅳ;in positive group :4 cases were classified into GradeⅠ,11 cases into GradeⅡ,10 cases into GradeⅢ,7 cases into GradeⅣ.The degree of liver fibrosis in the negative group was lower than that in the positive group,P =0.002 .In the negative group,the serum TBIL after operation was 28.3 (1 1 .2 ,55 .7 )μmol /L,vs.positive group 17 .3 (12 .2 ,46 .7 )μmol /L.There was no significant difference between the two groups,P =0.785 .The cumulative survival rate of the two groups was compared with the log-rank test,and the negative group was higher than that of the positive group,P =0.034. Conclusions The infection of CMV may aggravate the degree of liver fibrosis,and be a prognostic factor of bili-ary atresia.关键词
胆道闭锁/巨细胞病毒感染/外科手术/预后Key words
Biliary Atresia/Cytomegalovirus Infections/Surgical Procedures,Operative/Prognosis引用本文复制引用
董昆,杨体泉,董淳强,刘强,陈超,苏成,张诚,王从军,刘如意..巨细胞病毒感染与胆道闭锁 Kasai 手术预后的关系[J].临床小儿外科杂志,2016,(1):23-25,45,4.基金项目
广西卫生厅计划课题，项目号Z2014026 （）
