国际眼科杂志Issue(2)：253-257,5.DOI:10.3980/j.issn.1672-5123.2016.2.14
年龄相关性黄斑变性替代治疗中移植排斥的综述
Review of graft rejection in age-related macular degeneration replacement therapy
摘要
Abstract
•Age -related macular degeneration ( AMD ) is the leading cause of blindness among the elderly worldwide. AMD is classified as either neovascular ( wet ) or non-neovascular ( dry ) .The dysfunction and loss of retinal pigment epithelial ( RPE ) cells is regarded as the main pathological changes of AMD.The recent development of regenerative medicine has witnessed RPE cell -replacement therapy as a new approach to treat AMD, resulting in obvious visual improvement in various studies. However, there are still many problems and challenges that remain unsolved, including graft rejection. This review introduces subretinal immune environment under both normal and AMD condition, putting emphasis on immune response to allogeneic RPE. Lastly, strategies to prevent graft rejection are discussed.关键词
年龄相关性黄斑变性/视网膜色素上皮/移植排斥Key words
age-related macular degeneration/retinal pigment epithelium/graft rejection引用本文复制引用
茅希颖,袁松涛,刘庆淮..年龄相关性黄斑变性替代治疗中移植排斥的综述[J].国际眼科杂志,2016,(2):253-257,5.基金项目
国家重点基础研究发展计划（973计划）（ No．2013CB967500，2011CB65102）@@@@sNational Basic Research Program of China （973 Program） （）
