国际眼科杂志Issue(2)：343-345,3.DOI:10.3980/j.issn.1672-5123.2016.2.39
糖尿病患者角膜朗格汉斯细胞与神经纤维病理改变的研究
Study on corneal Langerhans cells and pathological changes of nerve fibers in diabetic patients
韩治华 1杨淑焕 1郭卫民 1刘喜燕2
作者信息
- 1. 710003 中国陕西省西安市，陕西省中医医院眼科
- 2. 710003 中国陕西省西安市，陕西省中医医院脾胃科
- 折叠
摘要
Abstract
Abstract•AIM:To study the relation between corneal epithelium Langerhans cells ( LCs ) and pathological changes of nerve fibers in patients with diabetic peripheral neuropathy in order to further analyze the pathogenesis and find the possible role of immune mechanism in this process.• METHODS: We selected 60 patients with diabetic neuropathy and 32 healthy controls to observe the morphology, number and length of corneal nerve fibers, corneal central sensation and the cell density of LCs to analyze the correlation of the two.•RESULTS: The number, length and the number of branches of corneal nerve fibers obvious declined in the patients with diabetic neuropathy.The curling degree of nerve fiber of diabetes group was obviously increased. The density of LCs at corneal central and peripheral areas in patients with diabetic neuropathy significantly increased compared to those of normal control group ( P<0.05).The correlation analysis results showed that there were linear correlation between LCs and nerve fiber density(r =0.461, P=0.011), LCs and nerve fiber length (r=0.519, P=0.002).And corneal central sensation decreased obviously in patients with diabetic neuropathy compared to that in normal control(P<0.05).•CONCLUSION: In patients with diabetic neuropathy, the nerve fibers are significantly impaired, corneal sensation decreases and number of LCs significantly increases, which suggests that the changes might be mediated by the immune mechanism.关键词
糖尿病周边神经病变/朗格汉斯细胞/神经纤维/免疫机制Key words
diabetic peripheral neuropathy/Langerhans cells/nerve fibers/immune mechanism引用本文复制引用
韩治华,杨淑焕,郭卫民,刘喜燕..糖尿病患者角膜朗格汉斯细胞与神经纤维病理改变的研究[J].国际眼科杂志,2016,(2):343-345,3.
