摘要
Abstract
Abstract•AIM: To compare the short-term efficacy of domestic and imported prostaglandins ( PGs ) for patients first diagnosed as primary open angle glaucoma.•METHODS: This study was a prospective positive drug control trial and 338 patients diagnosed as primary open angle glaucoma at the first time.According to patients' wills, they were divided into the experiment group ( 181 cases) and the control group ( 157 cases ) . Domestic latanoprost eye drops with 0.05g/L was used for 3mo in the experimental group while imported travoprost eye drops with 0.04g/L was used in the control group for 3mo.All patients were typically treated at 21∶00 every day within a 3mo period. Intraocular pressure ( IOP ) was measured before treatments and post treatments at 1, 2 and 3mo respectively, in each group.•RESULTS:For the experimental group, IOP was 28.32± 5.72, 21.84 ±4.63, 19.53 ±4.04 and 18.15 ±3.35mmHg before treatments and post treatments at 1, 2 and 3mo respectively, showing a significant difference among various time points(F=370.019,P=0.000),and the IOPs were markedly lower post treatments than those before treatments (all P<0.01).For the control group, IOP was 27.6±5.14, 21.91±5.22,19.80±4.26 and 18.76±3.46mmHg before treatments and post treatments at 1, 2 and 3mo respectively, showing a significant difference among various time points(F=306.052,P=0.000),and the IOP were markedly lower post treatments than those before treatments (all P<0.01).The difference of IOP level was not significant at post-treatment 1, 2 and 3mo respectively between two groups (P=0.144,0.456, 0.051).•CONCLUSION: Domestic latanoprost eye drops can reduce IOP effectively, with a suitable price, and it can be used as a first choice for primary open angle glaucoma patients in the basic-level hospitals.关键词
拉坦前列素/曲伏前列素/开角型青光眼Key words
latanoprost/travoprost/open angle glaucoma
