四川医学Issue(2)：135-137,138,4.DOI:10.16252/j.cnki.issn1004-0501-2016.02.005
成都地区人乳头瘤病毒感染现状及其亚型分布的回顾性分析
Retrospective Analysis of Infection and Subtype Distribution of Human Papilloma Virus in Chengdu
摘要
Abstract
Objective To analyze the infection status and the distribution of gene subtypes of cervical human papilloma virus ( HPV) in Chengdu. Methods We used gene chip typing technique to detect the gene subtypes of cervical HPV infection of 9075 cases of women. Results In the 9075 cases,the total positive rate of HPV infection was 32. 88% (2984/9075), containing high risk subtypes 25. 51% (2315/9075),and low risk subtypes 7. 37% (669/9075), and the difference was statistically signifi-cant (P<0. 01). The top 5 high risk type of HPV infection rate were HPV-52, HPV-16,HPV-58,HPV-53 and HPV-51 subtype. In the types of infection,single infection, double infection and multiple infection rates were respectively 21. 63% (1963/9075), 7. 19% (653/9075) and 4. 06% (368/9075). There were two peaks in the infection age, the first one was in the <25 years old group, and the second was in the >55 years old group. Compared with other groups, the difference was statistically significant (P<0. 01). Conclution Women in Chengdu area were mainly infected with high risk HPV infection,and the main types of in-fection were HPV-52,HPV-16,HPV-58,HPV-53 and HPV-51. We need more follow-up to patients with high risk HPV infection. The HPV genotyping detection was beneficial to early detection and early treatment of cervical cancer,and it also had great value for the study of HPV vaccine.关键词
人乳头瘤病毒/基因型/宫颈癌/核酸分子杂交Key words
human papilloma virus/genotype/cervical cancer/nucleic acid hybridization分类
医药卫生引用本文复制引用
赵丽,王文娟,刘成桂..成都地区人乳头瘤病毒感染现状及其亚型分布的回顾性分析[J].四川医学,2016,(2):135-137,138,4.基金项目
四川省卫生厅项目(编号:120516) （编号:120516）
