四川医学Issue(2)：164-166,167,4.DOI:10.16252/j.cnki.issn1004-0501-2016.02.013
坦索罗辛单药治疗后加用索利那新对良性前列腺增生体膀胱过度活动症的疗效观察
Efficacy Observation of Solifenacin after Treatment with Tamsulosin Monotherapy on Patients with Benign Prostatic Hyperplasia Accompanied with Overative Bladder
黄建林 1廖勇 1安宇 1熊国兵 1邱明星1
作者信息
- 1. 四川省医学科学院·四川省人民医院泌尿外科，四川 成都610072
- 折叠
摘要
Abstract
Objective To observe the therapeutic effect of solifenacin on male patients who still have overative bladder af-ter treatment with tamsulosin monotherapy for benign prostatic hyperplasia accompanied with lower urinary tract symptoms. Meth-ods Clinically selected over 50-year-old male patients who had benign prostatic hyperplasia accompanied with lower urinary tract symptoms. Firstly, all of the patients received tamsulosin treatments (0. 2 mg) for 4 weeks, after evaluating ,patients who still had OAB symptoms would be included in this observation group and then,treated the group with solifenacin (5mg) and tamsulosin (0. 2mg ) for 4 weeks. The observation items included the International Prostate Symptom Score (IPSS), the quality of life index ( QOL) , the symptom score ( OABSS) , the maximum flow rate ( Qmax) , and residual urine volume ( PVR) , etc. Results A-mong 112 patients who received tamsulosin treatment for 4 weeks,62 patients (55. 4%) met the inclusion criteria and 58 patients completed the study, the average age was 67. 2 years old. IPSS score ( 14. 4 to 10. 8 ) , QOL index ( 4. 4 to 3. 2 ) and OABSS (6. 1 to 3. 9) were significantly improved. Although the symptom score of IPSS during urinary storage period was significantly im-proved (10. 8 to 7. 4), the symptoms of IPSS during micturition period were not significantly changed, the PVR and Qmax had no significant changes before and after treatment. Conclusion Solifenacin had a safe and effective result on male patients with be-nign prostatic hyperplasia accompanied with lower urinary tract symptoms who still had overative bladder after treatment of tamsulo-sin.关键词
M受体阻滞剂/肾上腺素能α受体阻滞剂/下尿路症状/膀胱过度活动症/良性前列腺增生Key words
M receptor blockers/adrenergic α receptor blockers/lower urinary tract symptoms/bladder hyperactivity/benign overative bladder分类
医药卫生引用本文复制引用
黄建林,廖勇,安宇,熊国兵,邱明星..坦索罗辛单药治疗后加用索利那新对良性前列腺增生体膀胱过度活动症的疗效观察[J].四川医学,2016,(2):164-166,167,4.
