山东医药2016，Vol.56Issue(8)：1-3,3.DOI:10.3969/j.issn.1002-266X.2016.08.001
SUMO特异性蛋白酶1在胰腺癌组织中的表达及其临床意义
Expression of SUMO specific protease 1 in pancrestic cancer and its clinical significance
摘要
Abstract
Objective To investigate the function of SUMO specific protease 1 (SENP1) in the occurrence and devel-opment of pancreatic cancer .Methods Forty-four cases of pancreatic cancer tissues and paired adjacent tissues were col -lected.The protein and mRNA expression of SENP 1 was detected by immunohistochemistry , Western blotting and RT-PCR, and we analyzed its relationship with the clinicopathological parameters .Results The SENP1 protein expression in the pancreatic cancer tissues was higher than that in the adjacent tissues (1.18 ±0.11 vs.0.57 ±0.04), and the positive rate of SENP1 protein expression in the pancreatic cancer tissues was higher than that in the adjacent tissues [90.9%(40/44) vs.13.6%(6/44)] (all P<0.01).The SENP1 mRNA expression in the pancreatic cancer tissues was higher than that in the adjacent tissues (79.33 ±2.33 vs.16.67 ±1.20), and the positive rate of SENP1 mRNA expression in the pancreatic cancer tissues was higher than that of the adjacent tissues [93.2%(41/44) vs.13.6%(6/44)] (all P<0.01).The positive protein expression of SENP1 was associated with pathological stage and vascular invasion in the pan -creatic cancer tissues (all P<0.05).But it was not associated with gender , age, tumor location, tumor size, differentia-tion and lymph node metastasis (all P>0.05).Conclusion SENP1 is over-expressed in the pancreatic cancer tissues and the overexpression of SENP 1 promotes the occurrence and development of pancreatic cancer.关键词
胰腺癌/SUMO特异性蛋白酶1/免疫组化Key words
pancreatic carcinoma/SUMO specific protease 1/immunohistochemistry分类
医药卫生引用本文复制引用
曹维,张海峰,周国雄..SUMO特异性蛋白酶1在胰腺癌组织中的表达及其临床意义[J].山东医药,2016,56(8):1-3,3.基金项目
国家自然科学基金资助项目(81072028) （81072028）
江苏省医学创新团队与领军人才项目(LJ201135). （LJ201135）
