山东医药2016，Vol.56Issue(8)：7-9,3.DOI:10.3969/j.issn.1002-266X.2016.08.003
VEGF基因多态性及吸烟在诱发非酒精性脂肪肝中的交互作用
Gene polymorphism of VEGF and its interaction with smoking in patients with non-alcoholic fatty liver disease
摘要
Abstract
Objective To observe the gene polymorphisms of vascular endothelial growth factor ( VEGF ) rs833061 and rs3025039 and to investigate their interaction with smoking in patients with non-alcoholic fatty liver disease ( NAFLD) . Methods Genotypes of VEGF rs833061 and rs3025039 in 341 patients with NAFLD (NAFLD group) and 246 control subjects ( control group ) were examined by polymerase chain reaction-based restriction fragment length polymorphism ( PCR-RFLP) .The unconditional logistic regression ( ULR) was performed to analyze the relationships between the geno-types and susceptibility to NAFLD .The interactions between genotypes of VEGF rs 833061 and rs3025039 and smoking in inducing NAFLD were explored by generalized multifactor dimensionality reduction ( GMDR) and unconditional Logistic re-gression method.Results The risk of NAFLD in VEGF rs833061 with genotype C (CC+CT) was higher than that of car-riers without C (TT) (all P<0.01), and the risk of NAFLD in rs3025039T gene carriers (TT+CT) was higher than that of carriers without genotype T (CC) (all P<0.01).Gene polymorphism of VEGF rs833061 had interactions with smoking in the process of NAFLD (P<0.01).The risk of NAFLD in rs833061 CC/CT genotype of smoking individuals was 4.93 times higher than that of TT genotype of non-smoking individuals .Conclusions VEGF gene polymorphism is associated with the risk of NAFLD.VEGF rs833061 and smoking have synergistic effects in the process of inducing NAFLD.关键词
非酒精性脂肪肝/血管内皮生长因子/基因多态性/易感性/交互作用Key words
non-alcoholic fatty liver disease/vascular endothelial growth factor/gene polymorphisms/susceptibility/interaction分类
医药卫生引用本文复制引用
王倩,吴鹏波,李明,罗和生,余媛洁,谭诗云,舒泳翔..VEGF基因多态性及吸烟在诱发非酒精性脂肪肝中的交互作用[J].山东医药,2016,56(8):7-9,3.基金项目
湖北省自然科学基金重点项目(2014CFA045). （2014CFA045）
