西安交通大学学报（医学版）Issue(2)：260-263,4.DOI:10.7652/jdyxb201602023
NIS mRNA 在分化型甲状腺癌中的表达及其临床意义
Expression of sodium iodide symporter mRNA and its clinical significance in differentiated thyroid carcinoma
摘要
Abstract
Objective To investigate the expression of sodium iodide symporter (NIS ) mRNA in differentiated thyroid Carcinoma (DTC)and further explore its value in clinical diagnosis and therapy of DTC. Methods The expression of NIS mRNA was detected and analyzed in 21 nodular goiter and 45 cases of DTC (including 35 cases of papillary thyroid carcinoma and 10 cases of follicular thyroid carcinoma)by using real-time fluorescent quantitative reverse transcription polymerase chain reaction (real-time RT-PCR).Results Compared with that in nodular goiter,the mRNA expression of NIS in DTC tissue was significantly decreased (P < 0.05 ). Moreover,the mRNA expression of NIS was significantly correlated with lymph node metastasis and AJCC stage, respectively.The expression of NIS mRNA in DTC with lymph node metastasis was significantly decreased compared with that in DTC without lymph node metastasis (P <0.05).In addition,the expression of NIS mRNA in Ⅱ-Ⅳstage DTC was significantly decreased compared with that in Ⅰ - Ⅱ stage DTC (P < 0.05 ).Conclusion Differential expression of NIS can provide evidence for individual 1 3 1 I therapy for DTC.关键词
分化型甲状腺癌/钠碘同向转运体(NIS)/放射性碘治疗/实时荧光定量 PCRKey words
differentiated thyroid carcinoma (DTC)/sodium iodide symporter (NIS)/OPN/1 3 1 I therapy/real-time RT-PCR分类
医药卫生引用本文复制引用
许建林,梁晓燕,南永刚,赵华,施常备..NIS mRNA 在分化型甲状腺癌中的表达及其临床意义[J].西安交通大学学报（医学版）,2016,(2):260-263,4.基金项目
陕西省科学技术研究发展计划项目(No.2014K11-01-02-16) Supported by the Science and Technology Project of Shaanxi Province (No.2014K11-01-02-16) （No.2014K11-01-02-16）
