西安交通大学学报（医学版）Issue(2)：268-272,5.DOI:10.7652/jdyxb201602025
ADM 及β-catenin 在人骨肉瘤中的表达及其临床意义
Expressions of ADM andβ-catenin in human osteosarcoma and their clinical significance
吴学元 1郝崔培 2郭池华 3马巍3
作者信息
- 1. 陕西省人民医院骨科，陕西西安 710068
- 2. 陕西省人民医院妇科，陕西西安 710068
- 3. 西安交通大学第一附属医院骨科，陕西西安 710061
- 折叠
摘要
Abstract
ABSTRACT:Objective To study the expressions of adrenomedullin (ADM)andβ-catenin in human osteosarcoma of different differentiation grading and their clinical significance.Methods We chose 33 cases of human osteosarcoma with different pathological grading (14 cases of high differentiation grading and 1 9 cases of low grading)and 10 cases of human osteochondroma to detect the expressions of ADM protein,total (T)β-catenin and phosphorylated (P)β-catenin using immunohistochemical method. Results The expression of ADM was detected in the cytoplasm.In osteosarcomas of higher and lower differentiation grading,the positive rate of ADM was 57.1% (8/14)and 100% (1 9/1 9),respectively,with significant differences (P =0.003<0.05).The expression of T-β-catenin was observed in both the cytoplasm and the nucleus in higher differentiation grading and in only cytoplasm in lower grading.In osteosarcomas of higher and lower differentiation grading,the positive rate of T-β-catenin was 85.7%(12/14)and 94.7% (18/1 9),with no significant difference (P =0.561>0.05).The expression of P-β-catenin was detected in the cytoplasm.In osteosarcomas of higher and lower differentiation grading,the positive rate of P-β-catenin was 35.7% (5/14)and 78.9% (1 5/1 9),with a significant difference (P =0.029 <0.05).There was a significant correlation between ADM and P-β-catenin (r =0.424,P =0.025<0.05),but no significant correlation between ADM and T-β-catenin (P = 0.078 > 0.05 )or between T-β-catenin and P-β-catenin (P = 0.052 > 0.05 ).Conclusion The expressions of ADM and P-β-catenin proteins and the different distributions of expression of T-β-catenin protein in cytoplasm and/or nucleus are important indicators for judging the pathological grading of osteo-sarcoma.关键词
肾上腺髓质素(ADM)/β-catenin/骨肉瘤/分化Key words
adrenomedullin (ADM)/β-catenin/osteosarcoma/differentiation分类
医药卫生引用本文复制引用
吴学元,郝崔培,郭池华,马巍..ADM 及β-catenin 在人骨肉瘤中的表达及其临床意义[J].西安交通大学学报（医学版）,2016,(2):268-272,5.
